Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening

Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening

In the present study, a small marine-derived natural products library was assessed for antibacterial potential. Among 36 isolated compounds, a number of <i>bis</i>-indole derivatives exhibited growth-inhibitory activity towards Gram-positive strains (<i>Bacillus subtilis</i>...

Full description

Bibliographic Details
Main Authors: Ahmed M. Sayed, Hani A. Alhadrami, Seham S. El-Hawary, Rabab Mohammed, Hossam M. Hassan, Mostafa E. Rateb, Usama Ramadan Abdelmohsen, Walid Bakeer
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Microorganisms
Subjects:
mrsa
trisindoline
antibacterial
antibiofilm
inverse virtual screening
gyrase-b
pyruvate kinase
marine natural products
Online Access:https://www.mdpi.com/2076-2607/8/2/293

Internet

https://www.mdpi.com/2076-2607/8/2/293

Similar Items