Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell

The intestinal epithelium fulfils pleiotropic functions in nutrient uptake, waste elimination, and immune surveillance while also forming a barrier against luminal toxins and gut-resident microbiota. Incessantly barraged by extraneous stresses, the intestine must continuously replenish its epithelia...

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Bibliographic Details
Main Authors: Nathalie Sphyris, Michael C. Hodder, Owen J. Sansom
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
Wnt
Online Access:https://www.mdpi.com/2072-6694/13/5/1000