Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry...

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Bibliographic Details
Main Authors: George Savidis, William M. McDougall, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Nicholas Renzette, Douglas R. Robbins, Zhiru Guo, Sharone Green, Timothy F. Kowalik, Abraham L. Brass
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
Zika virus
dengue virus
yellow fever virus
flavivirus
arbovirus
EMC
AXL
CRISPR/Cas9 screen
MORR
RNAi screen
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307689

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http://www.sciencedirect.com/science/article/pii/S2211124716307689

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