Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins[S]

Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins[S]

The liver plays a central role in metabolism and mediating insulin action. To dissect the effects of insulin on the liver in vivo, we have studied liver insulin receptor knockout (LIRKO) mice. Because LIRKO livers lack insulin receptors, they are unable to respond to insulin. Surprisingly, the most...

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Bibliographic Details
Main Authors: Ji Miao, Joel T. Haas, Praveen Manthena, Yanning Wang, Enpeng Zhao, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Sudha B. Biddinger
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
hepatic insulin signaling
cholesterol biosynthesis
sterol regulatory element binding protein
liver insulin receptor knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376550

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http://www.sciencedirect.com/science/article/pii/S0022227520376550

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