Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis

Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis

Summary: Despite the high incidence of male infertility, only 30% of infertile men receive a causative diagnosis. To explore the regulatory mechanisms governing human germ cell function in normal and impaired spermatogenesis (crypto), we performed single-cell RNA sequencing (>30,000 cells). We fi...

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Bibliographic Details
Main Authors: Sara Di Persio, Tobias Tekath, Lara Marie Siebert-Kuss, Jann-Frederik Cremers, Joachim Wistuba, Xiaolin Li, Gerd Meyer zu Hörste, Hannes C.A. Drexler, Margot Julia Wyrwoll, Frank Tüttelmann, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Sandra Laurentino, Nina Neuhaus
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports Medicine
Subjects:
male germline stem cells
spermatogonial stem cells
male infertility
impaired spermatogenesis
single-cell RNA sequencing
human spermatogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121002536

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http://www.sciencedirect.com/science/article/pii/S2666379121002536

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