The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

The LKB1 tumor suppressor as a biomarker in mouse and human tissues.

Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1 protein is a serine-threonine kinase that phosphoryla...

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Bibliographic Details
Main Authors: Yuji Nakada, Thomas G Stewart, Christopher G Peña, Song Zhang, Ni Zhao, Nabeel Bardeesy, Norman E Sharpless, Kwok-Kin Wong, D Neil Hayes, Diego H Castrillon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3783464?pdf=render

Internet

http://europepmc.org/articles/PMC3783464?pdf=render

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