Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-<i>d</i>]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-<i>d</i>]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-<i>d</i>]pyrimidines. The series synthesized offers a chemical diversity in C-7 whereas C-2 (3-hydroxyphenyl) and C-4 gr...

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Bibliographic Details
Main Authors: Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie Aude Hiebel, Stéphane Bourg, Pascal Bonnet, Reine Nehmé, Philippe Morin, Nathalie Percina, Justine Corret, Béatrice Vallée, Remy le Guevel, Marie-Lise Jourdan, Hélène Bénédetti, Sylvain Routier
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
pyridopyrimidine
synthesis
PI3K and mTOR kinase inhibition
molecular modeling
cell effects
Online Access:https://www.mdpi.com/1420-3049/26/17/5349

Internet

https://www.mdpi.com/1420-3049/26/17/5349

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