Accumulation of Insoluble α-Synuclein in Dementia with Lewy Bodies

The α-synuclein (αSN) protein is thought to play a central role in the pathogenesis of neurodegenerative diseases where it aggregates to form intracellular inclusions. We have used Western blotting to examine the expression levels and solubility of αSN in brain homogenates from dementia with Lewy bo...

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Bibliographic Details
Main Authors: Bruce C.V. Campbell, Qiao-Xin Li, Janetta G. Culvenor, Pekka Jäkälä, Roberto Cappai, Konrad Beyreuther, Colin L. Masters, Catriona A. McLean
Format: Article
Language:English
Published: Elsevier 2000-06-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100902869