HPLC–MS and HPLC–MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat

HPLC–MS and HPLC–MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat

Xiao-xu-ming decoction (XXMD) is a traditional Chinese medicine that has been widely used to treat theoplegia and its sequelae. This paper reports the development of three separate assays based on reversed phase high-performance liquid chromatography–mass spectrometry (HPLC–MS) and HPLC–MS/MS for th...

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Bibliographic Details
Main Authors: Yilin Wang, Chunguang Ding, Caisheng Wu, Kehe Du, Jinlan Zhang, Hailin Qin, Jinfeng Hou, Guanhua Du
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Xiao-Xu-Ming decoction
HPLC–MS
HPLC–MS/MS
Pharmacokinetics
Oroxylin A-7-O-glucuronide
Wogonoside
Liquiritigenin
Cimifugin
5-O-methylvisammiol
Glycyrrhizic acid
Glycyrrhetinic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000214

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