Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus

Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus

Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of the hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) of A/Changchun/01/2009 (H1N...

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Bibliographic Details
Main Authors: Xianliang Ji, Zhiguang Ren, Na Xu, Lingnan Meng, Zhijun Yu, Na Feng, Xiaoyu Sang, Shengnan Li, Yuanguo Li, Tiecheng Wang, Yongkun Zhao, Hualei Wang, Xuexing Zheng, Hongli Jin, Nan Li, Songtao Yang, Jinshan Cao, Wensen Liu, Yuwei Gao, Xianzhu Xia
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Viruses
Subjects:
influenza
virus-like particles
membrane-anchored cholera toxin B
ricin toxin B
cross-protection
intranasal administration
Online Access:http://www.mdpi.com/1999-4915/8/4/115

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http://www.mdpi.com/1999-4915/8/4/115

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