Carboxypeptidase U (CPU, TAFIa, CPB2) in Thromboembolic Disease: What Do We Know Three Decades after Its Discovery?

Carboxypeptidase U (CPU, TAFIa, CPB2) in Thromboembolic Disease: What Do We Know Three Decades after Its Discovery?

Procarboxypeptidase U (proCPU, TAFI, proCPB2) is a basic carboxypeptidase zymogen that is converted by thrombin(-thrombomodulin) or plasmin into the active carboxypeptidase U (CPU, TAFIa, CPB2), a potent attenuator of fibrinolysis. As CPU forms a molecular link between coagulation and fibrinolysis,...

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Bibliographic Details
Main Authors: Karen Claesen, Joachim C. Mertens, Dorien Leenaerts, Dirk Hendriks
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
arterial thrombosis
carboxypeptidase B2
carboxypeptidase U
fibrinolysis
thrombin-activatable fibrinolysis inhibitor
thromboembolic diseases
Online Access:https://www.mdpi.com/1422-0067/22/2/883

Internet

https://www.mdpi.com/1422-0067/22/2/883

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