Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells

Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells

Novel caged nitroxides (nitroxide donors) with near-infrared two-photon (TP) responsive character, 2,2,6,6-tetramethyl-1-(1-(2-(4-nitrophenyl)benzofuran-6-yl)ethoxy)piperidine (2a) and its regioisomer 2b, were designed and synthesized. The one-photon (OP) (365 ± 10 nm) and TP (710–760 nm) triggered...

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Bibliographic Details
Main Authors: Ayato Yamada, Manabu Abe, Yoshinobu Nishimura, Shoji Ishizaka, Masashi Namba, Taku Nakashima, Kiyofumi Shimoji, Noboru Hattori
Format: Article
Language:English
Published: Beilstein-Institut 2019-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
caged compound
nitroxide
photolysis
radical
theranostics
two-photon
Online Access:https://doi.org/10.3762/bjoc.15.84

Internet

https://doi.org/10.3762/bjoc.15.84

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