Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent

Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent

Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a synthetic derivative of oleanolic acid, a triterpene, with apoptosis-inducing activity in a wide range of cancer cells. Induction of apoptosis by CDDO-Me is associated with the generation of reactive oxygen species (ROS) and inhibit...

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Bibliographic Details
Main Authors: Subhash C. Gautam, Ali S. Arbab, Nadimpalli R. S. Varma, Yongbo Liu, Xiaohua Gao, Dorrah Deeb
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
pancreatic cancer
CDDO-Me
ROS
hTERT
telomerase activity
Online Access:http://www.mdpi.com/1420-3049/18/3/3250

Internet

http://www.mdpi.com/1420-3049/18/3/3250

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