Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents

Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents

Myeloproliferative neoplasms (MPN), are clonal hematopoietic stem cell (HSC) disorders driven by gain-of-function mutations in JAK2 (JAK2-V617F), CALR or MPL genes. MPN treatment options currently mainly consist of cytoreductive therapy with hydroxyurea and JAK2 inhibitors such as ruxolitinib and fe...

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Bibliographic Details
Main Authors: Jan Stetka, Radek C. Skoda
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2021-03-01
Series:Biomedical Papers
Subjects:
mpn
myeloproliferative neoplasms
jak2
mouse model
pre-clinical models
novel therapies
Online Access:https://biomed.papers.upol.cz/artkey/bio-202101-0005_mouse-models-of-myeloproliferative-neoplasms-for-pre-clinical-testing-of-novel-therapeutic-agents.php

Internet

https://biomed.papers.upol.cz/artkey/bio-202101-0005_mouse-models-of-myeloproliferative-neoplasms-for-pre-clinical-testing-of-novel-therapeutic-agents.php

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