Cannabidiol, among other cannabinoid drugs, modulates prepulse inhibition of startle in the SHR animal model: implications for schizophrenia pharmacotherapy

Cannabidiol, among other cannabinoid drugs, modulates prepulse inhibition of startle in the SHR animal model: implications for schizophrenia pharmacotherapy

Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder....

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Bibliographic Details
Main Authors: Fernanda Fiel Peres, Raquel Levin, Valéria Almeida, Antonio Waldo Zuardi, Jaime E Hallak, José Alexandre Crippa, Vanessa Costhek Abilio
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Pharmacology
Subjects:
Cannabidiol
Schizophrenia
Animal Models
prepulse inhibition
endocannabinoid system
cannabinoid drugs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00303/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00303/full

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