Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD

Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD

Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. The mechanisms that link early adiposity with late-onset chronic diseases are poorly characterised. We developed a mouse model of early adiposity through litter size reduction. Mice reared in sm...

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Bibliographic Details
Main Authors: Francesc Ribas-Aulinas, Silvia Ribo, Marcela Parra-Vargas, Antonio Fernández-Pérez, Judith Cebrià, Maria Guardiola-Perello, Marta Ramon-Krauel, Carles Lerin, Ruben Diaz, Susana G. Kalko, Mario Vallejo, Antoni Díez-Noguera, Trinitat Cambras, Josep C. Jimenez-Chillaron
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
Developmental origins of health and disease (DOHaD)
Childhood obesity
Circadian rhythm
Litter size reduction
Time-restricted feeding (TRF)
Non-alcoholic fatty liver disease (NAFLD)
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000028

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http://www.sciencedirect.com/science/article/pii/S2212877821000028

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