Lung Tumorigenesis Alters the Expression of Slit2-exon15 Splicing Variants in Tumor Microenvironment

Lung Tumorigenesis Alters the Expression of Slit2-exon15 Splicing Variants in Tumor Microenvironment

Slit2 expression is downregulated in various cancers, including lung cancer. We identified two Slit2 splicing variants at exon15—Slit2-WT and Slit2-ΔE15. In the RT-PCR analyses, the Slit2-WT isoform was predominantly expressed in all the lung cancer specimens and in their normal l...

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Bibliographic Details
Main Authors: Ming-Fang Wu, Cheng-Yen Chuang, Pinpin Lin, Wei-Ting Chen, Shang-Er Su, Chen-Yi Liao, Ming-Shiou Jan, Jinghua Tsai Chang
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
Slit2 splicing variants
lung cancer
pneumothorax
tumor microenvironment
kRas<sup>G12D</sup>
LPS treatment
inflammation
Online Access:https://www.mdpi.com/2072-6694/11/2/166

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https://www.mdpi.com/2072-6694/11/2/166

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