Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.

CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms. Two severe CFTR mutations (CFTRsev) cause complete loss of CFT...

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Bibliographic Details
Main Authors: Jessica LaRusch, Jinsei Jung, Ignacio J General, Michele D Lewis, Hyun Woo Park, Randall E Brand, Andres Gelrud, Michelle A Anderson, Peter A Banks, Darwin Conwell, Christopher Lawrence, Joseph Romagnuolo, John Baillie, Samer Alkaade, Gregory Cote, Timothy B Gardner, Stephen T Amann, Adam Slivka, Bimaljit Sandhu, Amy Aloe, Michelle L Kienholz, Dhiraj Yadav, M Michael Barmada, Ivet Bahar, Min Goo Lee, David C Whitcomb, North American Pancreatitis Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4102440?pdf=render