A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

Abstract Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the deve...

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Bibliographic Details
Main Authors: Vid Mlakar, Edouard Morel, Simona Jurkovic Mlakar, Marc Ansari, Fabienne Gumy-Pause
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroblastoma
RAS-MAPK
ALK
RAS
MEK1/2
ERK1/2
Online Access:https://doi.org/10.1186/s13046-021-01967-x

Internet

https://doi.org/10.1186/s13046-021-01967-x

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