Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhibition of cell proliferation.

Bibliographic Details
Main Authors: Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J. Sharff, Gerard Bricogne, Patrick R. Griffin, Joseph Kissil, Tina Izard
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03648-4

Internet

https://doi.org/10.1038/s41467-018-03648-4

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