Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography

A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE...

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Bibliographic Details
Main Authors: Rien Ritawidya, Barbara Wenzel, Rodrigo Teodoro, Magali Toussaint, Mathias Kranz, Winnie Deuther-Conrad, Sladjana Dukic-Stefanovic, Friedrich-Alexander Ludwig, Matthias Scheunemann, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
cyclic nucleotide phosphodiesterase
pde2a radioligand
nitro-precursor
fluorine-18
in vitro autoradiography
pet imaging
Online Access:https://www.mdpi.com/1420-3049/24/22/4149

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https://www.mdpi.com/1420-3049/24/22/4149

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