Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Abstract Background The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. The present study investigated the effects of the flavonoid apigenin on the PD-L1 expression and the tumorigenesis of melanoma. Methods Th...

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Bibliographic Details
Main Authors: Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu, Yueguang Wu, Duchuang Wang, Shanshan Wang, Fang Liu, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu, Han Liu
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma
PD-L1
CD274
Apigenin
Flavonoid
STAT1
Online Access:http://link.springer.com/article/10.1186/s13046-018-0929-6

Internet

http://link.springer.com/article/10.1186/s13046-018-0929-6

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