A high-content platform for physiological profiling and unbiased classification of individual neurons

A high-content platform for physiological profiling and unbiased classification of individual neurons

Summary: High-throughput physiological assays lose single-cell resolution, precluding subtype-specific analyses of activation mechanism and drug effects. We demonstrate APPOINT (automated physiological phenotyping of individual neuronal types), a physiological assay platform combining calcium imagin...

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Bibliographic Details
Main Authors: Daniel M. DuBreuil, Brenda M. Chiang, Kevin Zhu, Xiaofan Lai, Patrick Flynn, Yechiam Sapir, Brian J. Wainger
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports: Methods
Subjects:
high-throughput calcium imaging
machine learning
dorsal root ganglia
nociceptor physiology
all-optical physiology
optogenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237521000047

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http://www.sciencedirect.com/science/article/pii/S2667237521000047

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