Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs

Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs

Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum dis...

Full description

Bibliographic Details
Main Authors: Joris Comhair, Jens Devoght, Giovanni Morelli, Robert J. Harvey, Victor Briz, Sarah C. Borrie, Claudia Bagni, Jean-Michel Rigo, Serge N. Schiffmann, David Gall, Bert Brône, Svetlana M. Molchanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorders
dorsal striatum
medium spiny neurons
glycine receptors
spontaneous activity
synaptic development
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00380/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00380/full

Similar Items