Phylogenetic analysis of the bacterial Pro-Pro-endopeptidase domain reveals a diverse family including secreted and membrane anchored proteins

Pro-Pro-endopeptidases (PPEP, EC 3.4.24.89) are secreted, zinc metalloproteases that have the unusual capacity to cleave a peptide bond between two prolines, a bond that is generally less sensitive to proteolytic cleavage. Two well studied members of the family are PPEP-1 and PPEP-2, produced by Clo...

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Bibliographic Details
Main Authors: Hans C van Leeuwen, Dick Roelofs, Jeroen Corver, Paul Hensbergen
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Current Research in Microbial Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517421000055