Recombinant Ricin Toxin Binding Subunit B (RTB) Stimulates Production of TNF-α by Mouse Macrophages Through Activation of TLR4 Signaling Pathway

Recombinant Ricin Toxin Binding Subunit B (RTB) Stimulates Production of TNF-α by Mouse Macrophages Through Activation of TLR4 Signaling Pathway

Ricin toxin binding subunit B (RTB) is a galactose-binding lectin protein derived from the beans of the castor oil plant (Ricinus communis). Our previous studies have reported a direct immunomodulatory effect of recombinant RTB, which stimulates RAW264.7 cells to produce cytokines including TNF-α. H...

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Bibliographic Details
Main Authors: Na Xu, Kaikai Yu, Haotian Yu, Jianxu Zhang, Yang Yang, Mingxin Dong, Yan Wang, Ying Chang, Yucheng Sun, Yanguang Hou, Chengbiao Sun, Jiayu Wan, Wensen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
ricin toxin binding subunit B
macrophage
TLR4
cytokine
signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.526129/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.526129/full

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