SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2.

SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2.

Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog is strictly regulated by Oct4/Sox2 heter...

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Bibliographic Details
Main Authors: Yongyan Wu, Zekun Guo, Haibo Wu, Xiaohai Wang, Lixia Yang, Xiaoyan Shi, Juan Du, Bo Tang, Wenzhong Li, Liping Yang, Yong Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3382131?pdf=render

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http://europepmc.org/articles/PMC3382131?pdf=render

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