PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all human protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, count...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-10-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/50416 |