Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase

Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase

The glycolytic enzyme and bacterial virulence factor of Listeria monocytogenes, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Lmo2459), ADP-ribosylated the small GTPase, Rab5a, and blocked phagosome maturation. This inhibitory activity localized within the NAD binding domain of GAPDH at the N...

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Bibliographic Details
Main Authors: Carmen Alvarez-Dominguez, David Salcines-Cuevas, Héctor Teran-Navarro, Ricardo Calderon-Gonzalez, Raquel Tobes, Isabel Garcia, Santiago Grijalvo, Alberto Paradela, Asunción Seoane, Felix J. Sangari, Manuel Fresno, Jorge Calvo-Montes, I. Concepción Pérez Del Molino Bernal, Sonsoles Yañez-Diaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
adjuvants
glyceraldehyde-3-phosphate-dehydrogenase
listeriosis
pneumonia
tuberculosis
vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.573348/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2020.573348/full

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