Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells

Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells

Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is an infectious disease mainly associated with poverty that affects millions of people worldwide. Since treatment for this disease relies only on the use of praziquantel, there is an urgent need to identify new antischistosomal...

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Bibliographic Details
Main Authors: Yuri Campelo, Alicia Ombredane, Andreanne G. Vasconcelos, Lucas Albuquerque, Daniel C. Moreira, Alexandra Plácido, Jefferson Rocha, Harold Hilarion Fokoue, Lydia Yamaguchi, Ana Mafud, Yvonne P. Mascarenhas, Cristina Delerue-Matos, Tatiana Borges, Graziella A. Joanitti, Daniel D.R. Arcanjo, Massuo J. Kato, Selma A. S. Kuckelhaus, Marcos P. N. Silva, Josué de Moraes, José Roberto S. A. Leite
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
piplartine
analogues
Schistosoma mansoni
cytotoxicity
Online Access:http://www.mdpi.com/1422-0067/19/6/1802

Internet

http://www.mdpi.com/1422-0067/19/6/1802

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