Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions of the RNA-binding protein (RBP) TDP-43, and often the presence of a GGGGCC ex...

Full description

Bibliographic Details
Main Authors: Erin G Conlon, Delphine Fagegaltier, Phaedra Agius, Julia Davis-Porada, James Gregory, Isabel Hubbard, Kristy Kang, Duyang Kim, The New York Genome Center ALS Consortium, Hemali Phatnani, Neil A Shneider, James L Manley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
amyotrophic lateral aclerosis
frontotemporal dementia
mRNA splicing
RNA binding proteins
Online Access:https://elifesciences.org/articles/37754

Internet

https://elifesciences.org/articles/37754

Similar Items