Vacuolar H<sup>+</sup>-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling

Vacuolar H<sup>+</sup>-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling

The vacuolar H<sup>+</sup>-adenosine triphosphatase (ATPase) subunit V0C (ATP6V0C), a proton-conducting, pore-forming subunit of vacuolar ATPase, maintains pH homeostasis and induces organelle acidification. The intracellular and extracellular pH of cancer cells affects their growth; how...

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Bibliographic Details
Main Authors: Sung Wook Son, Gia Cac Chau, Seong-Tae Kim, Sung Hee Um
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
vacuolar H<sup>+</sup>-ATPase subunit V0C
aerobic glycolysis
esophageal cancer cell
pyruvate kinase muscle isozyme 2 (PKM2)
motility
Online Access:https://www.mdpi.com/2073-4409/8/10/1137

Internet

https://www.mdpi.com/2073-4409/8/10/1137

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