An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens

An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens

All nucleated mammalian cells express major histocompatibility complex (MHC) proteins that present peptides on cell surfaces for immune surveillance. These MHC-presented peptides (pMHC) are necessary for directing T-cell responses against cells harboring non-self antigens derived from pathogens or f...

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Bibliographic Details
Main Authors: Niclas Olsson, Marlene L. Heberling, Lichao Zhang, Suchit Jhunjhunwala, Qui T. Phung, Sarah Lin, Veronica G. Anania, Jennie R. Lill, Joshua E. Elias
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
antigen presentation
IFN-γ
MHC
cancer
HLA
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.662443/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.662443/full

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