Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information

Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information

The move from OTU-based to sOTU-based analysis, while providing additional resolution, also introduces computational challenges. We demonstrate that one popular method of dealing with sOTUs (building a de novo tree from the short sequences) can provide incorrect results in human gut metagenomic stud...

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Bibliographic Details
Main Authors: Stefan Janssen, Daniel McDonald, Antonio Gonzalez, Jose A. Navas-Molina, Lingjing Jiang, Zhenjiang Zech Xu, Kevin Winker, Deborah M. Kado, Eric Orwoll, Mark Manary, Siavash Mirarab, Rob Knight
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mSystems
Subjects:
SEPP
amplicon sequencing
microbial community analysis
phylogenetic placement
Online Access:https://doi.org/10.1128/mSystems.00021-18

Internet

https://doi.org/10.1128/mSystems.00021-18

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