Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets

Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vascular remodeling leading to elevation of pulmonary artery pressure, right ventricular hypertrophy, and death. Currently, there are no cure exists for PAH. Magnesium lithospermate B (MLB) is the major component of Salv...

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Bibliographic Details
Main Authors: Yafeng Wang, Delong Duo, Yingjun Yan, Rongyue He, Xinan Wu
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Magnesium lithospermate B
Pulmonary arterial hypertension
Endothelial-to-mesenchymal transition
Potential targets
Hypoxia
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307538

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http://www.sciencedirect.com/science/article/pii/S0753332220307538

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