Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

Summary: Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC). Here, we found that Smad7 mediates intestinal inflammation by limiting the PDL2/1-PD1...

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Main Authors: Lucien P. Garo, Amrendra K. Ajay, Mai Fujiwara, Vanessa Beynon, Chantal Kuhn, Galina Gabriely, Supriya Sadhukan, Radhika Raheja, Stephen Rubino, Howard L. Weiner, Gopal Murugaiyan
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719309696

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http://www.sciencedirect.com/science/article/pii/S2211124719309696

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