An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF Aß42 and an APOE ε4 allele

An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF Aß42 and an APOE ε4 allele

Objective: Low concentrations of cerebrospinal fluid (CSF) amyloid-beta (Aβ-42) are associated with increased risk of cognitive decline in Parkinson's disease (PD). We sought to determine whether APOE genotype modifies the rate of cognitive decline in PD patients with low CSF Aβ-42 compared to...

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Bibliographic Details
Main Authors: Marian Shahid, Jeehyun Kim, Katherine Leaver, Taylor Hendershott, Delphine Zhu, Brenna Cholerton, Victor W. Henderson, Lu Tian, Kathleen L. Poston
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Cognitive impairment
APOE ɛ4
Amyloid
Cerebrospinal fluid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306557

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118306557

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