Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

The phosphoinositide 3-kinase (PI3K) /AKT/mammalian target of rapamycin (mTOR) signaling pathway is frequently mutated in cancers, leading to increased cell proliferation, migration, and chemoresistance. Currently, a number of small molecule inhibitors of the PI3K/AKT/mTOR signaling pathway have bee...

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Bibliographic Details
Main Authors: Xiaoqing Hu, Meihui Xia, Jiabin Wang, Huimei Yu, Jiannan Chai, Zejun Zhang, Yupei Sun, Jing Su, Liankun Sun
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
PI3K/AKT/mTOR
Cell growth
Apoptosis
p62
Mcl-1
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220305904

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220305904

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