Attenuation of Virulent Porcine Reproductive and Respiratory Syndrome Virus Strain CH-1a and Genetic Variation of ORF5 Gene

Attenuation of Virulent Porcine Reproductive and Respiratory Syndrome Virus Strain CH-1a and Genetic Variation of ORF5 Gene

To develop a modified live vaccine (MLV) against porcine reproductive and respiratory syndrome virus (PRRSV), virulent CH-1a strain was attenuated by serial passages up to 130 passage (P130) in Marc-145 cells. The virulence and immune efficacy of the attenuated CH-1a were evaluated in pigs. The resu...

Full description

Bibliographic Details
Main Authors: Xue-hui CAI, Guo-jun WU, Yong-gang LIU, Guang-qing LIU, Wen-da SHI, Shu-jie WANG, Ping MA, Cheng-jun LI, Wen-yu HAN
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Journal of Integrative Agriculture
Subjects:
attenuation
porcine reproductive and respiratory syndrome virus
genetic variation
ORF5 gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311912604614

Internet

http://www.sciencedirect.com/science/article/pii/S2095311912604614

Similar Items