Insights into GBA Parkinson's disease pathology and therapy with induced pluripotent stem cell model systems

While the link between GBA and Parkinson's disease (PD) was initially unexpected, it is now well established that GBA mutations are the most frequent genetic risk for PD. GBA has also been linked to sporadic PD, dementia with Lewy bodies, and ageing. Thus, GBA represents a promising target to c...

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Bibliographic Details
Main Authors: Pascale Baden, Cong Yu, Michela Deleidi
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
GBA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300324