Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.
<h4>Background</h4>PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor gene implicated in a wide variety of human cancers, including glioblastoma. PTEN is a major negative regulator of the PI3K/Akt signaling pathway. Most human gliomas show high levels...
Main Authors: | Venkata Ramesh Dasari, Kiranpreet Kaur, Kiran Kumar Velpula, Meena Gujrati, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Jasti S Rao |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-04-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20436671/?tool=EBI |
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