Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report

Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report

Abstract Background Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from diagnosis. Here, we report the case of a...

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Bibliographic Details
Main Authors: Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup, Karin Schilbach
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic carcinoma
Therapeutic vaccines
Neoepitope-derived peptides
T-cell responses
CDR3 sequences
Online Access:http://link.springer.com/article/10.1186/s12967-018-1382-1

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http://link.springer.com/article/10.1186/s12967-018-1382-1

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