Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03178-z |
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DOAJ |
| language |
English |
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Article |
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DOAJ |
| author |
Jayaram Vijayakrishnan James Studd Peter Broderick Ben Kinnersley Amy Holroyd Philip J. Law Rajiv Kumar James M. Allan Christine J. Harrison Anthony V. Moorman Ajay Vora Eve Roman Sivaramakrishna Rachakonda Sally E. Kinsey Eamonn Sheridan Pamela D. Thompson Julie A. Irving Rolf Koehler Per Hoffmann Markus M. Nöthen Stefanie Heilmann-Heimbach Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharaoh Alison M. Dunning Julian Peto Frederico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL Consortium Mel Greaves Martin Zimmerman Claus R. Bartram Martin Schrappe Martin Stanulla Kari Hemminki Richard S. Houlston |
| spellingShingle |
Jayaram Vijayakrishnan James Studd Peter Broderick Ben Kinnersley Amy Holroyd Philip J. Law Rajiv Kumar James M. Allan Christine J. Harrison Anthony V. Moorman Ajay Vora Eve Roman Sivaramakrishna Rachakonda Sally E. Kinsey Eamonn Sheridan Pamela D. Thompson Julie A. Irving Rolf Koehler Per Hoffmann Markus M. Nöthen Stefanie Heilmann-Heimbach Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharaoh Alison M. Dunning Julian Peto Frederico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL Consortium Mel Greaves Martin Zimmerman Claus R. Bartram Martin Schrappe Martin Stanulla Kari Hemminki Richard S. Houlston Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia Nature Communications |
| author_facet |
Jayaram Vijayakrishnan James Studd Peter Broderick Ben Kinnersley Amy Holroyd Philip J. Law Rajiv Kumar James M. Allan Christine J. Harrison Anthony V. Moorman Ajay Vora Eve Roman Sivaramakrishna Rachakonda Sally E. Kinsey Eamonn Sheridan Pamela D. Thompson Julie A. Irving Rolf Koehler Per Hoffmann Markus M. Nöthen Stefanie Heilmann-Heimbach Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharaoh Alison M. Dunning Julian Peto Frederico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL Consortium Mel Greaves Martin Zimmerman Claus R. Bartram Martin Schrappe Martin Stanulla Kari Hemminki Richard S. Houlston |
| author_sort |
Jayaram Vijayakrishnan |
| title |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_short |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_full |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_fullStr |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_full_unstemmed |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia |
| title_sort |
genome-wide association study identifies susceptibility loci for b-cell childhood acute lymphoblastic leukemia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-04-01 |
| description |
While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3. |
| url |
https://doi.org/10.1038/s41467-018-03178-z |
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doaj-6a850276ab0d4ba1a6215db9280b774f2021-05-11T09:36:00ZengNature Publishing GroupNature Communications2041-17232018-04-01911910.1038/s41467-018-03178-zGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemiaJayaram Vijayakrishnan0James Studd1Peter Broderick2Ben Kinnersley3Amy Holroyd4Philip J. Law5Rajiv Kumar6James M. Allan7Christine J. Harrison8Anthony V. Moorman9Ajay Vora10Eve Roman11Sivaramakrishna Rachakonda12Sally E. Kinsey13Eamonn Sheridan14Pamela D. Thompson15Julie A. Irving16Rolf Koehler17Per Hoffmann18Markus M. Nöthen19Stefanie Heilmann-Heimbach20Karl-Heinz Jöckel21Douglas F. Easton22Paul D. P. Pharaoh23Alison M. Dunning24Julian Peto25Frederico Canzian26Anthony Swerdlow27Rosalind A. Eeles28ZSofia Kote-Jarai29Kenneth Muir30Nora Pashayan31The PRACTICAL ConsortiumMel Greaves32Martin Zimmerman33Claus R. Bartram34Martin Schrappe35Martin Stanulla36Kari Hemminki37Richard S. Houlston38Division of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Molecular Genetic Epidemiology, German Cancer Research CentreNorthern Institute for Cancer Research, Newcastle UniversityWolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle UniversityWolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle UniversityDepartment of Haematology, Great Ormond Street HospitalDepartment of Health Sciences, University of YorkDivision of Molecular Genetic Epidemiology, German Cancer Research CentreDepartment of Paediatric and Adolescent Haematology and Oncology, Leeds General InfirmaryMedical Genetics Research Group, Leeds Institute of Molecular Medicine, University of LeedsPaediatric and Familial Cancer Research Group, Institute of Cancer Sciences, St. Mary’s HospitalNorthern Institute for Cancer Research, Newcastle UniversityDepartment of Human Genetics, Institute of Human Genetics, University of HeidelbergDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of BonnDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of BonnDepartment of Genomics, Institute of Human Genetics, Life & Brain Centre, University of BonnInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–EssenDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of CambridgeDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of CambridgeDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways LaboratoryDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical MedicineGenomic Epidemiology Group, German Cancer Research Center (DKFZ)Division of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchInstitute of Population Health, University of ManchesterDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of CambridgeCentre for Evolution and Cancer, Institute of Cancer ResearchDepartment of Paediatric Haematology and Oncology, Hannover Medical SchoolDepartment of Human Genetics, Institute of Human Genetics, University of HeidelbergGeneral Paediatrics, University Hospital Schleswig-HolsteinDepartment of Paediatric Haematology and Oncology, Hannover Medical SchoolDivision of Molecular Genetic Epidemiology, German Cancer Research CentreDivision of Genetics and Epidemiology, The Institute of Cancer ResearchWhile GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3.https://doi.org/10.1038/s41467-018-03178-z |