Exposure to Sub-inhibitory Concentrations of the Chemosensitizer 1-(1-Naphthylmethyl)-Piperazine Creates Membrane Destabilization in Multi-Drug Resistant Klebsiella pneumoniae

Exposure to Sub-inhibitory Concentrations of the Chemosensitizer 1-(1-Naphthylmethyl)-Piperazine Creates Membrane Destabilization in Multi-Drug Resistant Klebsiella pneumoniae

Antimicrobial efflux is one of the important mechanisms causing multi-drug resistance (MDR) in bacteria. Chemosensitizers like 1-(1-naphthylmethyl)-piperazine (NMP) can inhibit an efflux pump and therefore can overcome MDR. However, secondary effects of NMP other than efflux pump inhibition are rare...

Full description

Bibliographic Details
Main Authors: João Anes, Sathesh K. Sivasankaran, Dechamma M. Muthappa, Séamus Fanning, Shabarinath Srikumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
chemosensitizers
1-(1-naphthylmethyl)-piperazine
membrane destabilization
NMP
secondary effects
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00092/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00092/full

Similar Items