Apoptotic Gastritis in Melanoma Patients Treated With PD-1-Based Immune Checkpoint Inhibition – Clinical and Histopathological Findings Including the Diagnostic Value of Anti-Caspase-3 Immunohistochemistry

Apoptotic Gastritis in Melanoma Patients Treated With PD-1-Based Immune Checkpoint Inhibition – Clinical and Histopathological Findings Including the Diagnostic Value of Anti-Caspase-3 Immunohistochemistry

BackgroundGastritis induced by checkpoint inhibitors (CPI) is a rare but severe drug-related side effect. The reference standard for confirming CPI-associated gastritis (CPI-assGastritis) is histopathological assessment; however, the histopathological features of CPI-assGastritis are not yet adequat...

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Bibliographic Details
Main Authors: Jan-Malte Placke, Josefine Rawitzer, Henning Reis, Jassin Rashidi-Alavijeh, Elisabeth Livingstone, Selma Ugurel, Eva Hadaschik, Klaus Griewank, Kurt Werner Schmid, Dirk Schadendorf, Alexander Roesch, Lisa Zimmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
melanoma
immune check inhibitor (ICI)
PD-1
gastritis
immune related adverse effects
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.725549/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.725549/full

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