Domain-swapped T cell receptors improve the safety of TCR gene therapy

Domain-swapped T cell receptors improve the safety of TCR gene therapy

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mis...

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Bibliographic Details
Main Authors: Michael T Bethune, Marvin H Gee, Mario Bunse, Mark S Lee, Eric H Gschweng, Meghana S Pagadala, Jing Zhou, Donghui Cheng, James R Heath, Donald B Kohn, Michael S Kuhns, Wolfgang Uckert, David Baltimore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
receptor biogenesis
cancer immunotherapy
protein engineering
autoimmunity
T cell
T cell receptor
Online Access:https://elifesciences.org/articles/19095

Internet

https://elifesciences.org/articles/19095

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