Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome

Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome

5-hydroxytryptamine receptor 5B (5-HT5B) is a gene coding for a G protein-coupled receptor (GPCR) that plays key roles in several neurodevelopmental disorders. Our previous study showed that disruption of 5-HT5B induced by lysine (K)-specific demethylase 6A (Kdm6a, also known as Utx) conditional kno...

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Bibliographic Details
Main Authors: Gang-Bin Tang, Ting-Wei Mi, Man-Lian Sun, Ya-Jie Xu, Shu-Guang Yang, Hong-Zhen Du, Saijilafu, Zhao-Qian Teng, Jun Gao, Chang-Mei Liu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:IBRO Reports
Subjects:
5-HT5B
UTX
Kabuki syndrome
Synaptic transmission
Anxiety
Memory
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830120300261

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http://www.sciencedirect.com/science/article/pii/S2451830120300261

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