Synthesis of the Hydroxamate Siderophore Nα-Methylcoprogen B in Scedosporium apiospermum Is Mediated by sidD Ortholog and Is Required for Virulence

Synthesis of the Hydroxamate Siderophore Nα-Methylcoprogen B in Scedosporium apiospermum Is Mediated by sidD Ortholog and Is Required for Virulence

Scedosporium species rank second among the filamentous fungi capable to colonize chronically the respiratory tract of patients with cystic fibrosis (CF). Nevertheless, there is little information on the mechanisms underpinning their virulence. Iron acquisition is critical for the growth and pathogen...

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Bibliographic Details
Main Authors: Yohann Le Govic, Vladimir Havlíček, Javier Capilla, Dominika Luptáková, Dayana Dumas, Nicolas Papon, Solène Le Gal, Jean-Philippe Bouchara, Patrick Vandeputte
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Scedosporium
iron uptake
extracellular siderophore
Nα-methyl coprogen B
virulence factor
xenosiderophores
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.587909/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2020.587909/full

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