B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.

B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.

The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype has generally been attributed to a proliferation defect in the cell cycle phase of G1.I...

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Bibliographic Details
Main Authors: Kirill V Tarasov, Yelena S Tarasova, Wai Leong Tam, Daniel R Riordon, Steven T Elliott, Gabriela Kania, Jinliang Li, Satoshi Yamanaka, David G Crider, Gianluca Testa, Ronald A Li, Bing Lim, Colin L Stewart, Yie Liu, Jennifer E Van Eyk, Robert P Wersto, Anna M Wobus, Kenneth R Boheler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2423619?pdf=render

Internet

http://europepmc.org/articles/PMC2423619?pdf=render

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