Oncogenic activation of ERG: A predominant mechanism in prostate cancer

Oncogenic activation of ERG: A predominant mechanism in prostate cancer

Prevalent gene fusions involving regulatory sequences of the androgen receptor (AR) regulated genes (primarily TMPRSS2) and protein coding sequences of nuclear transcription factors of the ETS gene family (predominantly ERG) result in unscheduled androgen dependent ERG expression in prostate cancer...

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Bibliographic Details
Main Authors: Taduru L Sreenath, Albert Dobi, Gyorgy Petrovics, Shiv Srivastava
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2011-01-01
Series:Journal of Carcinogenesis
Subjects:
ERG
prostate cancer
TMPRSS2-ERG
oncoprotein
androgen receptor
patient stratification
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2011;volume=10;issue=1;spage=37;epage=37;aulast=Sreenath

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http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2011;volume=10;issue=1;spage=37;epage=37;aulast=Sreenath

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